In general, looking back at 2024 and looking forward to 2025, I think it is appropriate to summarize it in four sentences: from grassroots to universal, from chaos to order, from depression to bubble, and from conservatism to reform. Next, I will share my thoughts and prospects with some events that I think are more representative.

BIO Protocol is an important innovator in the DeSci industry. By building a decentralized biotechnology research and commercialization ecosystem, it provides a fair and transparent cooperation platform for researchers, investors and patient communities. Its comprehensive token economic model and strong cooperation network make BIO Protocol have significant potential in the rapidly growing DeSci market.

OpenAI CEO Sam Altman announced last week the technology products that will be released in 2025. They are: AGI (general artificial intelligence), Agents, a better GPT-4o upgrade, better memory storage, better context windows, "Grow up mode", deep research features, better Sora, and better personalization.

In a d/acc concept article published today, Ethereum co-founder Vitalik Buterin proposed setting up a global "soft pause button" to replace the dangerous artificial general intelligence (AGI) race. The function of this button is to "reduce the world's available computing power by about 90%-99% for 1-2 years at a critical moment, buying more preparation time for humans."

Aave Governance Forum recently proposed a proposal to peg USDe to Tether's USDT at a 1:1 ratio, which has raised concerns about potential conflicts of interest, especially given the difference in decoupling risks between the two. The proposal, which is currently in the comment stage, aims to replace the existing Chainlink USDe/USD oracle by hard-coding the USDe price to match the USDT price in the Aave pricing feed to ensure seamless integration and reduce disruptions caused by USDe price fluctuations.

Interactive Brokers is tightening its exposure to MicroStrategy (MSTR) by gradually increasing margin requirements to a minimum of 50% on January 13, 2025. This is a clear sign that they are preparing for the upcoming volatility.

Ethereum co-founder Vitalik Buterin shared his latest views on d/acc (decentralized acceleration) in his latest blog post, pointing out that there is actually an important connection between d/acc and cryptocurrency. d/acc extends the underlying values of cryptocurrency, such as decentralization, censorship resistance, and open economic and social concepts, to other technical fields. As early adopters, cryptocurrency users' communities naturally become testing grounds for d/acc technology. The community attaches great importance to practice rather than empty talk, making the cryptocurrency community an ideal incubator for d/acc technology, especially in group-oriented fields such as information and biodefense. Cryptocurrency practitioners are good at working together. In addition, cryptocurrency technologies such as blockchain and zero-knowledge proofs can be applied to the construction of d/acc's financial, governance and social media infrastructure, and to protect privacy. Today, many prediction markets are based on blockchain and are becoming more complex, decentralized, and democratized. Collaboration on cryptocurrency-related technologies, such as formal verification, software and hardware security, and adversarial robust governance techniques, is both beneficial to cryptocurrency projects and key to the d/acc goal of enhancing the security and robustness of the Ethereum blockchain, wallets, and DAOs, while reducing the vulnerability of network attacks (including the threat of super-intelligent AI). In addition to these direct intersections, there is another critical common focus: funding mechanisms. This is another way that the cryptocurrency community can help d/acc: by carefully exploring these funding mechanisms and making them work in their own environment, preparing for broader adoption of broader open source science and technology.